Cardiac Allograft Rejection and Vasculopathy Critical Role of Donor Tissue Expression of Programmed Death Ligand-1 in Regulating
نویسندگان
چکیده
Yagita, Yuan, Shirine Dada, Indira Guleria, Chaorui Tian, M. Javeed Ansari, Tahiro Shin, Hideo Jun Yang, Joyce Popoola, Shakila Khandwala, Nidyanandh Vadivel, Vijay Vanguri, Xueli Cardiac Allograft Rejection and Vasculopathy Critical Role of Donor Tissue Expression of Programmed Death Ligand-1 in Regulating Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2008 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/CIRCULATIONAHA.107.741025 2008;117:660-669; originally published online January 22, 2008; Circulation. http://circ.ahajournals.org/content/117/5/660 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Critical role of donor tissue expression of programmed death ligand-1 in regulating cardiac allograft rejection and vasculopathy.
BACKGROUND Allograft vasculopathy is a major limiting factor in the long-term success of cardiac transplantation. T cells play a critical role in initiation of cardiac allograft rejection and allograft vasculopathy. The negative T-cell costimulatory pathway PD-1:PDL1/PDL2 (programmed death-1:programmed death ligand-1/2) plays an important role in regulating alloimmune responses. We investigated...
متن کاملPDL1 is required for peripheral transplantation tolerance and protection from chronic allograft rejection.
The PD-1:PDL pathway plays an important role in regulating alloimmune responses but its role in transplantation tolerance is unknown. We investigated the role of PD-1:PDL costimulatory pathway in peripheral and a well established model of central transplantation tolerance. Early as well as delayed blockade of PDL1 but not PDL2 abrogated tolerance induced by CTLA4Ig in a fully MHC-mismatched car...
متن کاملMechanisms of chronic cardiac allograft rejection.
Chronic rejection in the form of cardiac allograft vasculopathy is one of the major factors that affects long-term graft and patient survival after heart transplantation. Whereas multiple factors contribute to the development of cardiac allograft vasculopathy, immunologic mechanisms play the predominant role in the chronic rejection process, because both alloimmune and autoimmune responses are ...
متن کاملSuppression of murine cardiac allograft arteriopathy by long-term blockade of CD40-CD154 interactions.
BACKGROUND The interaction between CD40 on antigen-presenting cells and CD40L on T cells is critical in allograft rejection. CD154 blockade suppresses allograft rejection, but the role of this pathway in allograft vasculopathy remains obscure. METHODS AND RESULTS A vascularized murine heterotopic cardiac transplant model was used to test whether perioperative CD154 blockade suppresses allogra...
متن کاملTobacco smoke exposure in either the donor or recipient before transplantation accelerates cardiac allograft rejection, vascular inflammation, and graft loss.
BACKGROUND Tobacco exposure in cardiac transplant recipients, before and after transplantation, may increase the risk of cardiac allograft vasculopathy and allograft loss, but no direct evidence for this phenomenon is forthcoming. In this experimental study, we investigated early consequences of tobacco smoke exposure in cardiac transplant donors and recipients with an emphasis on alloinflammat...
متن کامل